35 Bible Verses for Those Battling Loneliness and Isolation

Loneliness is one of those aches that’s hard to describe to someone who’s never felt it deeply. It’s more than being alone; you can be surrounded by people and still feel completely isolated. It’s that hollow feeling that no one truly sees you, understands your struggles, or would miss you if you disappeared tomorrow. In our hyper-connected world, genuine loneliness has somehow become an epidemic, leaving people desperate for real connection.

But here’s what I’ve learned: loneliness often drives us to the most profound encounters with God. When human relationships fail us or simply aren’t available, we discover that our souls were designed for communion with our Creator. The same God who said, “it is not good for man to be alone,” also promises to never leave us or forsake us. He doesn’t just observe our isolation from a distance; He enters into it with us.

These verses aren’t quick fixes for deep loneliness, but they are invitations into a relationship with the One who knows you completely and loves you unconditionally. Sometimes the path out of isolation begins with embracing the presence of God in our solitude.

Table of Contents

Bible Verses for Those Battling Loneliness and Isolation

1. Deuteronomy 31:8 – He Will Never Leave You nor Forsake You

The Lord himself goes before you and will be with you; he will never leave you nor forsake you. Do not be afraid; do not be discouraged.

New International Version (NIV)

2. Psalm 25:16 – Turn to Me and Be Gracious to Me

Turn to me and be gracious to me, for I am lonely and afflicted.

English Standard Version (ESV)

3. Isaiah 41:10 – Do Not Fear, for I Am with You

Fear not, for I am with you; Be not dismayed, for I am your God. I will strengthen you, Yes, I will help you, I will uphold you with My righteous right hand.

New King James Version (NKJV)

4. Matthew 28:20 – I Am with You Always

And be sure of this: I am with you always, even to the end of the age.

New Living Translation (NLT)

5. Psalm 68:6 – God Sets the Lonely in Families

God provides homes for those who are deserted. He leads prisoners out into prosperity, but the rebellious live in a scorched land.

Christian Standard Bible (CSB)

6. Psalm 139:7-10 – Where Can I Go from Your Spirit?

Where can I go from Your Spirit? Or where can I flee from Your presence? If I ascend to heaven, You are there; If I make my bed in Sheol, behold, You are there. If I take the wings of the dawn, If I dwell in the remotest part of the sea, Even there Your hand will lead me, And Your right hand will lay hold of me.

New American Standard Bible (NASB)

7. John 14:18 – I Will Not Leave You as Orphans

I will not leave you comfortless: I will come to you.

King James Version (KJV)

8. Psalm 23:4 – Even Though I Walk Through the Darkest Valley

Even though I walk through the darkest valley, I fear no evil; for you are with me; your rod and your staff they comfort me.

New Revised Standard Version (NRSV)

9. Hebrews 13:5 – Never Will I Leave You

Don’t be obsessed with getting more material things. Be relaxed with what you have. Since God assured us, “I’ll never let you down, never walk off and leave you,” we can boldly quote, God is there, ready to help; I’m fearless no matter what. Who or what can get to me?

The Message (MSG)

10. Psalm 34:18 – The Lord Is Close to the Brokenhearted

The Lord is close to the brokenhearted and saves those who are crushed in spirit [He rescues those whose spirit is broken by sorrow].

Amplified Bible (AMP)

11. Romans 8:38-39 – Nothing Can Separate Us from God’s Love

For I am convinced that neither death, nor life, nor angels, nor demons, nor things present, nor things to come, nor powers, nor height, nor depth, nor anything else in creation will be able to separate us from the love of God in Christ Jesus our Lord.

New English Translation (NET)

12. 1 Kings 19:10 – I Alone Am Left

He said, “I have been very zealous for the Lord God of Hosts, but the Israelites have abandoned Your covenant, torn down Your altars, and killed Your prophets with the sword. I alone am left, and they’re looking for me to take my life.”

Holman Christian Standard Bible (HCSB)

13. Psalm 27:10 – Though My Father and Mother Forsake Me

Even if my father and mother abandon me, you will take care of me.

Contemporary English Version (CEV)

14. Isaiah 49:15-16 – Can a Mother Forget Her Nursing Child?

“Can a woman forget her own baby and not love the child she bore? Even if a mother should forget her child, I will never forget you. Jerusalem, I can never forget you! I have written your name on the palms of my hands.

Good News Translation (GNT)

15. Psalm 142:4 – Look and See, There Is No One at My Right Hand

Look around and see. No one cares about me. I have no place of safety. No one cares whether I live or die.

New Century Version (NCV)

16. John 16:32 – Yet I Am Not Alone

Indeed, a time is coming, and has now come, when you will be scattered, each of you to your own home, leaving me all alone. Yet I am not alone because the Father is with me.

International Standard Version (ISV)

17. Psalm 73:23 – Yet I Am Always with You

Nevertheless, I am continually with You; You have taken hold of my right hand.

Tree of Life Version (TLV)

18. 2 Timothy 4:16-17 – But the Lord Stood at My Side

At my first defense no one came to help me, but all deserted me. May it not be counted against them! But the Lord stood by me and strengthened me, so that through me the message would be fully proclaimed and all the Gentiles would hear it. So I was delivered from the lion’s mouth.

Lexham English Bible (LEB)

19. Ecclesiastes 4:9-12 – Two Are Better Than One

Two are better than one, because they have a good reward for their labor. For if they fall, the one will lift up his fellow; but woe to him who is alone when he falls, and doesn’t have another to lift him up. Again, if two lie together, then they have warmth; but how can one keep warm alone? If a man prevails against one who is alone, two shall withstand him; and a threefold cord is not quickly broken.

World English Bible (WEB)

20. Psalm 102:7 – I Am Like a Desert Owl

I watch, and am become like a sparrow that is alone upon the housetop.

American Standard Version (ASV)

21. Isaiah 54:10 – Though the Mountains Be Shaken

For the mountains may depart and the hills be removed, but my steadfast love shall not depart from you, and my covenant of peace shall not be removed, says the Lord, who has compassion on you.

Revised Standard Version (RSV)

22. Psalm 22:24 – He Has Not Hidden His Face from Him

For he has not despised or disdained the suffering of the afflicted one; he has not hidden his face from him but has listened to his cry for help.

New American Bible (NAB)

23. Jeremiah 1:8 – Do Not Be Afraid of Them

Be not afraid of their faces: for I am with thee to deliver thee, saith the Lord.

Douay-Rheims Bible (DRB)

24. Genesis 28:15 – I Am with You and Will Watch Over You

And, behold, I am with thee, and will keep thee whithersoever thou goest, and will bring thee again into this land; for I will not leave thee, until I have done that which I have spoken to thee of.

English Revised Version (ERV)

25. Psalm 146:9 – The Lord Watches Over the Foreigner

Jehovah preserveth the strangers; He upholdeth the fatherless and widow; But the way of the wicked He turneth upside down.

Young’s Literal Translation (YLT)

26. 1 Peter 5:7 – Cast All Your Anxiety on Him

casting all your care upon him, for he cares about you.

Darby Translation (DARBY)

27. Joshua 1:5 – No One Will Be Able to Stand Against You

There shall not any man be able to stand before thee all the days of thy life: as I was with Moses, so I will be with thee: I will not fail thee, nor forsake thee.

Weymouth New Testament (WNT)

28. Psalm 91:15 – He Will Call on Me, and I Will Answer Him

He schal clepe me, and Y schal here hym; Y am with hym in tribulacioun, Y schal delyuere hym, and Y schal glorifie hym.

Wycliffe Bible (WYC)

29. Zephaniah 3:17 – The Lord Your God Is with You

The Lord thy God in the middes of thee is mightie: he wil saue, he wil reioyce ouer thee with ioye: he wil quiet himselfe in his loue: he wil reioyce ouer thee with ioye.

Geneva Bible (GNV)

30. Isaiah 43:2 – When You Pass Through the Waters

When thou goest through the waters, I wylbe with thee, and the strong fluddes shall not ouer flowe thee. When thou walkest in the fyre, it shal not burne thee, and the flame shall not kyndle vpon thee.

Bishop’s Bible

31. John 14:16 – Another Advocate to Help You

And I wyll praye the father: and he shall geve you another comforter yt he maye byde with you ever.

Tyndale Bible

32. Psalm 37:25 – I Was Young and Now I Am Old

I have been young and now I am old, yet I have never seen the righteous forsaken or their children begging bread.

The Living Bible (TLB)

33. Romans 8:26 – The Spirit Helps Us in Our Weakness

And in a similar way, the Holy Spirit takes hold of us in our human frailty to empower us in our weakness. For example, at times we don’t even know how to pray, or know the best things to ask for. But the Holy Spirit rises up within us to super-intercede on our behalf, pleading to God with emotional sighs too deep for words.

The Passion Translation (TPT)

34. Psalm 147:3 – He Heals the Brokenhearted

He heals the brokenhearted and gently binds up their wounds.

The Voice Bible (VOICE)

35. Matthew 11:28 – Come to Me, All You Who Are Weary

“Come to me, all you who are tired and are carrying heavy loads. I will give you rest.

New International Reader’s Version (NIrV)

Our Thoughts on What the Bible Says About Loneliness and Isolation

Scripture never minimizes the pain of loneliness or offers cheap platitudes about just “getting over it.” Instead, it acknowledges that isolation is a real human struggle that even the most faithful people face. David felt abandoned, Elijah believed he was the only faithful prophet left, and even Jesus experienced the profound loneliness of being forsaken on the cross. This tells us that feeling alone doesn’t indicate spiritual failure.

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What’s remarkable is how often these verses connect our loneliness directly to God’s presence. It’s not that God removes us from isolation, but rather that He enters into it with us. Sometimes the deepest spiritual growth happens during seasons of solitude, when we’re forced to discover that our souls truly can find rest in God alone.

The Bible also consistently points us toward community, but it’s important to note that human relationships are meant to supplement, not replace, our relationship with God. When we try to fill God-sized holes in our hearts with human connection alone, we’ll always come up empty. But when we’re rooted in His love first, we’re better equipped for healthy relationships with others.

Say This Prayer

Father, this loneliness feels so heavy sometimes. Even when I’m surrounded by people, I can feel completely isolated and misunderstood. Thank You for seeing me in this place and for understanding exactly what I’m going through. Help me to believe, especially on the hardest days, that You really are with me and that I’m never as alone as I feel.

When the silence feels overwhelming, help me to sense Your presence in new ways. Teach me to find comfort in Your Word and peace in prayer, even when my emotions tell me no one is listening. Show me how to rest in Your love instead of constantly searching for validation from others.

If it’s Your will, please bring genuine friendships and community into my life. But until then, help me to grow closer to You through this season of solitude. Use this time to deepen my faith and increase my dependence on You. When I do connect with others, let it be from a place of wholeness rather than desperate need.

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Thank You for being the friend who sticks closer than a brother and for promising to never leave me. Fill this lonely space with Your presence.

In Jesus’ name, Amen.

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